PROTON PUMP INHIBITORS(PPIs)

What is proton pump inhibitors (PPIs)?

Proton pump inhibitors are medicines that work on the cells of stomach and reducing the production of acid.

What is the use of proton pump inhibitors?

treat ulcers in

duodenum
stomach

What drug is a proton pump inhibitor?

rabeprazole
pantaprazole
rabeprazole
Lansoprazole
Omeprazole
Esomeprazole

How’s proton pump inhibitors work?

What is the mechanism of action of proton pump inhibitors?

proton pump inhibitors Bind to Proton Pumps in the Stomach.

proton pumps are responsible for acid secretion in stomach.

PPIs work by irreversibly blocking the H+/K+ ATPase enzyme, which is found within the parietal cells of the stomach. By this inhibit the production of acid in stomach.

How acid secret in stomach?

1. H+ ions and bicarbonate ion(HCO3-) are formed inside parietal cells combination of CO2 and water presence of carbonic anhydrase enzyme.

2. Cl- is pumped inside parietal cell in exchange of HCO3-.

3. H+ ions are pumped into gastric lumen by K+/H+ pump.

4. Cl- moves out of parietal cell into lumen by diffusion

H+/K+-ATPase (proton pump) located in the luminal membrane of parietal cells

What are the side effects of proton pump inhibitors?

Headache
Diarrhea
Nausea
Vomiting

When should you take a proton pump inhibitor?

proton pump inhibitor should be taken before meal (about 30 to 40 min before meal).

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