RENIN ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS)
what is renin angiotensin aldosterone system (RAAS)?
The Renin-Angiotensin-Aldosterone System (RAAS) is a hormone system of the body that is essential for the regulation of blood pressure and fluid balance.
The Renin-Angiotensin-Aldosterone System (RAAS) is a hormone system of the body that is essential for the regulation of blood pressure and fluid balance.
What does the renin angiotensin aldosterone system do?
Regulate of blood pressure and fluid balance.
When renal blood flow is reduced, juxtaglomerular cells in the kidneys secrete renin directly into circulation.
Rennin convert to angiotensin I by angiotensinogen (released by the liver)
angiotensin I convert to to angiotensin II by the angiotensin-converting enzyme (ACE) { released by the surface of vascular endothelial cells of lungs }
Angiotensin II is vasoconstrictive that causes blood vessels to narrow, resulting in increased blood pressure.
Angiotensin II also stimulates the secretion of the hormone aldosterone (from the adrenal cortex).
Aldosterone causes the renal tubules to increase the reabsorption of sodium and water into the blood, while at the same time causing the excretion of potassium (to maintain electrolyte balance). This increases the volume of extracellular fluid in the body, which also increases blood pressure.
If the RAS is abnormally active, blood pressure will be too high. So several types of drugs are used like:
ACE inhibitors
ARBs
Renin inhibitors
They interrupt different steps in this system to improve blood pressure. These drugs are one of the primary ways to control high blood pressure, heart failure, kidney failure, and harmful effects of diabetes.
Regulate of blood pressure and fluid balance.
How does the renin angiotensin aldosterone system regulate blood pressure?
When renal blood flow is reduced, juxtaglomerular cells in the kidneys secrete renin directly into circulation.
Rennin convert to angiotensin I by angiotensinogen (released by the liver)
angiotensin I convert to to angiotensin II by the angiotensin-converting enzyme (ACE) { released by the surface of vascular endothelial cells of lungs }
Angiotensin II is vasoconstrictive that causes blood vessels to narrow, resulting in increased blood pressure.
Angiotensin II also stimulates the secretion of the hormone aldosterone (from the adrenal cortex).
Aldosterone causes the renal tubules to increase the reabsorption of sodium and water into the blood, while at the same time causing the excretion of potassium (to maintain electrolyte balance). This increases the volume of extracellular fluid in the body, which also increases blood pressure.
If the RAS is abnormally active, blood pressure will be too high. So several types of drugs are used like:
ACE inhibitors
ARBs
Renin inhibitors
They interrupt different steps in this system to improve blood pressure. These drugs are one of the primary ways to control high blood pressure, heart failure, kidney failure, and harmful effects of diabetes.
what are renin angiotensin aldosterone system inhibitors importance?
To treat hypertension
To treat hypertension
what are renin angiotensin aldosterone system inhibitors?
ACE inhibitors
angiotensin II receptor blockers
Renin-Inhibitors
ACE inhibitors
angiotensin II receptor blockers
Renin-Inhibitors
What are ACE inhibitors drugs?
Benazepril
Captopril
Enalapril
Fosinopril
Lisinopril
Moexioril
Perinopril
Quinapril
What are angiotensin II receptor blockers drugs?
Azilsartan
Candesartan
Eprosartan
Irbesartan
Losartan
Olmesartan
Telmisartan
Valsartan
Benazepril
Captopril
Enalapril
Fosinopril
Lisinopril
Moexioril
Perinopril
Quinapril
What are angiotensin II receptor blockers drugs?
Azilsartan
Candesartan
Eprosartan
Irbesartan
Losartan
Olmesartan
Telmisartan
Valsartan
What are Renin-Inhibitors drugs?
Enalkiren
Remikiren
Aliskiren
Enalkiren
Remikiren
Aliskiren
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